Editorial: The Ischemic Penumbra: Still the Target for Stroke Therapies?
نویسندگان
چکیده
1 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, 2 Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA, 3 Department of Cognitive Science, Johns Hopkins University, Baltimore, MD, USA, 4 Clinical Neurosciences, University of Cambridge, Cambridge, UK, 5 INSERM U894, Centre de Psychiatrie et Neurosciences, Hôpital Sainte-Anne, Sorbonne Paris Cité, Paris, France
منابع مشابه
Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.
BACKGROUND The ability to quickly and efficiently identify the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Early and accurate identification of potentially salvageable versus irreversibly infarcted brain tissue may enable selection of the most appropriate candidates for early stroke therapies and identify patients who may st...
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The idea that there exist 2 ischemic thresholds in the pathogenesis of cerebral infarction came from seminal microelectrode studies of the baboon cortex the late 1970s1,2 that measured the effects of progressive reductions in cerebral blood flow (CBF). These studies described a level of CBF reduction that led to cessation of cortical evoked responses in the absence of terminal increases in extr...
متن کاملEvolving paradigms in neuroimaging of the ischemic penumbra.
Identification of the ischemic penumbra in the acute stroke clinical setting is an important goal for stroke researchers and clinicians. Various models for imaging the penumbra with MRI have been proposed, including the pioneering diffusion-perfusion mismatch model and later multivariate approaches. A number of multicenter clinical trials are now under way to test these models and confirm the u...
متن کاملBest measure of ischemic penumbra: positron emission tomography.
The ischemic penumbra was defined by Astrup et al 1 as brain tissue perfused at a level within the thresholds of functional impairment and morphological integrity, which has the capacity to recover if perfusion is improved. Because tolerance of tissue to ischemic damage is dependent on residual flow and duration of flow disturbance,2 the ischemic penumbra characterizes a transient condition: it...
متن کاملTargeting the ischemic penumbra.
BACKGROUND In the last 3 decades, and from a therapeutic point of view, the classical concept of ischemic penumbra based on hemodynamic and electrophysiological parameters has loosened up the rigidity of therapeutic windows in acute stroke management. Thirty years later, the ischemic penumbra is an evolved concept that presents more applications. Thus, the ischemic penumbra is a diagnostic targ...
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